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Preventive effect of eugenol on PAF and ethanol-induced gastric mucosal damage
R Capasso1, L Pinto, M L Vuotto
1Department of Pharmaceutical Sciences, Via Ponte Don Melillo, 84084, Fisciano, Salerno, Italy.
Fitoterapia
|August 10, 2000
Abstract:
This study examines the anti-ulcerogenic activity of eugenol, a natural compound obtained from many natural sources. Gastric ulcers, induced by administration of two ulcerogenic agents, i.e. platelet activating factor (PAF) and ethanol, were dose-dependently and significantly reduced by eugenol (10-100 mg/kg, p.o.) pre-treatment. Eugenol was able to reduce not only the number of ulcers but also the gravity of lesions.