Breaking the COPI monopoly on Golgi recycling
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Updated: Sep 17, 2026

Quantitative Localization of a Golgi Protein by Imaging Its Center of Fluorescence Mass
Published on: August 10, 2017
B Storrie1, R Pepperkok, T Nilsson
1Dept of Biochemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA. storrie@vt.edu
Abstract:
The unexpected discovery of a transport pathway from the Golgi to the endoplasmic reticulum (ER) independent of COPI coat proteins sheds light on how Golgi resident enzymes and protein toxins gain access to the ER from as far as the trans Golgi network. This new pathway provides an explanation for how membrane is recycled to allow for an apparent concentration of anterograde cargo at distinct stages of the secretory pathway. As signal-mediated COPI-dependent recycling also involves the concentration of resident proteins into retrograde COPI vesicles, the main bulk of lipids must be recycled, possibly through a COPI-independent pathway.
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