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[The antibiotic sensitivity of microorganisms isolated from newborn infants]
1Kyiv Scientific-Research Institute of Epidemiology and Infectious Diseases, Ministry of Public Health of Ukraine.
Insights
Antibiotic resistance is increasing in bacteria from newborns, necessitating revised treatment strategies. Hospital environments may contribute to newborn colonization by resistant strains.
Area of Science:
- Microbiology
- Infectious Diseases
- Clinical Pharmacy
Context:
- Neonatal intensive care units (NICUs) are susceptible to bacterial colonization.
- Antibiotic resistance poses a significant threat to vulnerable infant populations.
- Hospital environmental surfaces can harbor multidrug-resistant bacteria.
Purpose:
- To assess antibiotic resistance patterns in bacterial strains isolated from neonates.
- To identify emerging resistance determinants to key antibiotics.
- To investigate the link between neonatal and hospital environmental strains.
Summary:
- A study analyzed 219 bacterial strains from newborns against 17 antibiotics.
- Significant increases in resistance (5.7-43%) were observed for cephalothins, aminoglycosides, and chloramphenicol.
- Resistance to ofloxacin and ciprofloxacin suggests novel resistance mechanisms.
Impact:
- Findings highlight the urgent need to re-evaluate antibiotic use in neonatal care.
- Identifies potential hospital-to-newborn transmission routes for resistant bacteria.
- Informs infection control strategies to protect vulnerable newborns.
Abstract:
Bacterial strains (219) isolated from newborn children were studied for their sensitivity to 17 antibiotics. In the case of the species studied the increase of resistance to cephalothin, cefazolin, cefotaxime, ceftriaxone, gentamicin, tobramycin, chloramphenicol by 5.7 to 43% was found. This evidenced for a necessity to revise the tactics of their further use for treatment and prophylaxis, while the identification of the strains resistant to ofloxacin and ciprofloxacin evidenced for the appearance of new resistance determinants. The high level of resistance to antibiotics and practically identical profile of antibiotics in the strains isolated from newborns and epidemiologically significant environmental objects in the examined hospitals do point to possible colonization of newborns by the hospital strains.