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[Hormonal changes in male patients with primary open angle glaucoma]
M Nowak1, E Swietochowska, K Jochan
1Zakładu Patofizjologii i Endokrynologii Slaskiej AM w Zabrzu.
Klinika Oczna
|August 10, 2000
Summary
Elevated cortisol levels may contribute to primary open angle glaucoma (POAG). This study found higher serum cortisol and urinary metabolites in POAG patients, suggesting endocrine system changes in POAG pathogenesis.
Area of Science:
- Endocrinology
- Ophthalmology
- Glaucoma Research
Context:
- Primary open angle glaucoma (POAG) is the most common form of glaucoma, with its pathogenesis not fully understood.
- Glucocorticoid hormones are suspected to play a role in POAG and ocular hypertension.
- Glucocorticoid receptors are present in ocular outflow tissue.
Purpose:
- To evaluate serum concentrations of hormones including total cortisol (TF), total testosterone (TT), free testosterone (FT), FSH, LH, ACTH, SHBG, DHEA-SO4, and urinary levels of free cortisol (UFF) and 17-OHCS in male POAG patients.
- To compare these hormone levels with a control group.
Summary:
- The study analyzed hormone levels in 30 male POAG patients (mean age 55 ± 13 years) treated for over two years, using RIA methods.
- Results showed significantly increased serum concentrations of total cortisol (TF) and free cortisol (UFF), as well as elevated urinary 17-OHCS, compared to controls.
- No significant differences were found in pituitary-gonadal axis hormone levels between POAG patients and the control group.
Impact:
- Findings suggest that alterations in the endocrine system, specifically elevated cortisol and its metabolites, are associated with the pathogenesis of POAG.
- This research highlights a potential link between hormonal imbalances and the development or progression of primary open angle glaucoma.