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[Tropoxin and cerebrovascular effects of serotonin]
R S Mirzoian1, A V Topchian, T S Gan'shina
1Laboratory of Cerebrovascular Disorder Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia.
Eksperimental'Naia I Klinicheskaia Farmakologiia
|August 10, 2000
Abstract:
The effect of serotonin on the brain blood supply was studied in rats before and after ischemic damage. The ischemic damage, induced by ligation of the middle meningeal artery, markedly enhanced the constrictor effect of serotonin on the brain vessels. Tropoxin, a 5HT2 receptor blocker, completely eliminated these cerebrovascular effects of serotonin.