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Updated: Oct 14, 2026

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
Published on: November 4, 2025
Cephalometric comparisons of craniofacial and upper airway structures in young children with obstructive sleep apnea
S Kawashima1, N Niikuni, L Chia-hung
1Department of Paediatric Dentistry, Nihon University School of Dentistry, Tokyo, Japan. kawashima-s@dent.nihon-u.ac.jp
Insights
Preschool children with obstructive sleep apnea often show jaw and tooth alignment issues, alongside a narrower airway. Cephalometric analysis is recommended for evaluating sleep apnea in young children.
Area of Science:
- Pediatric Dentistry
- Sleep Medicine
- Orthodontics
Background:
- Obstructive sleep apnea (OSA) is a common condition in children.
- Dentofacial morphology and pharyngeal airway dimensions are implicated in OSA pathogenesis.
Purpose of the Study:
- To investigate the dentofacial morphology and pharyngeal airway space in preschool children with OSA.
- To identify cephalometric predictors of OSA in this age group.
Main Methods:
- Cephalometric analysis was performed on 15 preschool children diagnosed with OSA.
- A control group of 30 nonapneic children was used for comparison.
- Measurements included mandibular position, incisor inclination, cranial base dimensions, and epipharyngeal airway space.
Main Results:
- Children with OSA frequently exhibited mandibular retrognathia and retroclined lower incisors.
- No significant differences in cranial base measurements were observed between OSA patients and controls.
- Apneic children presented with a significantly narrower epipharyngeal airway space compared to controls.
Conclusions:
- Obstructive sleep apnea in preschool children is associated with specific dentofacial abnormalities and reduced pharyngeal airway dimensions.
- Adenoidal hypertrophy and abnormal facial skeleton development likely contribute to OSA.
- Cephalometric analysis is a valuable tool for presurgical evaluation of pediatric OSA.
Abstract:
We studied 15 children of preschool age who had obstructive sleep apnea syndrome to evaluate their dentofacial morphology in relation to the pharyngeal airway space. We found that (1) sleep apnea was often associated with mandibular retrognathia, (2) the lower incisors tended to exhibit a retrocline, (3) there were no significant differences in angular and linear measurements in the cranial base between patients with sleep apnea and a control group of 30 nonapneic children, and (4) the apneic children had a narrower epipharyngeal airway space than did the controls. These findings suggest that obstructive sleep apnea is probably caused by both adenoidal hypertrophy and abnormal development of the facial skeleton. We highly recommend cephalometric analysis as a valuable tool for conducting the presurgical evaluation of sleep apnea in children of preschool age.
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