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[Lassa fever].

K Fleischer1, B Köhler, A Kirchner

  • 1Abteilung für Tropenmedizin, Missionsärztliche Klinik GmbH Würzburg. missio-tropmed@mail.uni-wuerzburg.de

Medizinische Klinik (Munich, Germany : 1983)
|August 10, 2000
PubMed
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A German student returning from West Africa developed Lassa fever, a highly contagious infection. Despite intensive care and ribavirin, she succumbed to hemorrhagic complications, highlighting the need for specialized training and rapid diagnostics.

Area of Science:

  • Tropical Medicine
  • Infectious Diseases
  • Virology

Background:

  • A 22-year-old German student presented with a 5-day fever of unknown origin after a 7-week trip to West Africa.
  • Initial diagnoses of malaria and typhoid were excluded, and she did not respond to antibiotics.

Observation:

  • The patient was transferred to the Department of Tropical Medicine with suspected Lassa fever.
  • Lassa fever virus was confirmed via PCR on day 10 of illness, based on travel history, fever, cough, pharyngitis, and thoracic pain.
  • The patient received intensive care in strict isolation, including barrier nursing, isolation suits, and intravenous ribavirin.

Findings:

  • The patient developed uncontrollable hemorrhage from multiple organs and skin, leading to volume deficiency shock.
  • Despite comprehensive intensive care and ribavirin treatment, the patient died on day 14 of illness.

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  • The case highlights the severe presentation and high mortality associated with Lassa fever.

    • Implications:

    • Emphasizes the critical need for specialized training in tropical medicine for diagnosing and managing highly contagious infections.
    • Underscores the importance of rapid diagnostics, strict isolation protocols, and intensive care for Lassa fever patients.
    • Necessitates robust public health strategies including contact tracing, psychological support for staff, and proper handling of infectious remains and waste.