Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hepatic polyploidy and liver growth control.

S Gupta1

  • 1Marion Bessin Liver Research Center, and Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA. sanjvgupta@pol.net

Seminars in Cancer Biology
|August 11, 2000
PubMed
Summary

Cellular polyploidy, common in mammalian tissues like the liver, is linked to cell aging and death. Genetic issues like DNA repair problems can cause polyploidy, potentially leading to organ failure or cancer.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Signal transduction within the nucleus by mitogen-activated protein kinase.

The Journal of biological chemistry·1992
Same author

Occurrence and mechanisms of glycopeptide resistance in gram-positive cocci.

Infectious agents and disease·1992
Same author

Interrelationship between ovine follicular fluid inhibin and serum albumin.

Indian journal of experimental biology·1992
Same author

Paraplegia following cisternal puncture in thoracic osteochondroma.

Indian pediatrics·1992
Same author

Changing profile of enteric fever--in summer-91.

The Journal of the Association of Physicians of India·1992
Same author

Preferential expression and activity of multidrug resistance gene 1 product (P-glycoprotein), a functionally active efflux pump, in human CD8+ T cells: a role in cytotoxic effector function.

Journal of clinical immunology·1992

Area of Science:

  • Cellular biology
  • Genetics
  • Mammalian tissue studies

Background:

  • Cellular polyploidy is a widespread phenomenon observed in differentiated mammalian tissues.
  • The liver, both in normal and pathological conditions, frequently exhibits polyploidy.
  • Increasing evidence highlights the role of polyploidy in cellular processes.

Purpose of the Study:

  • To explore the significance of cellular polyploidy in mammalian tissues.
  • To investigate the relationship between polyploidy and cellular differentiation, senescence, and apoptosis.
  • To examine the potential genetic underpinnings and consequences of hepatocellular polyploidy.

Main Methods:

  • Literature review and synthesis of current research on cellular polyploidy.
  • Analysis of existing data on polyploidy in liver tissues.
  • Examination of working models linking polyploidy to disease.

Main Results:

  • Cells with higher ploidy levels show increased progression towards terminal differentiation and senescence.
  • Higher ploidy classes are associated with a greater probability of apoptosis.
  • Impaired DNA repair mechanisms are implicated as a cause of hepatocellular polyploidy.

Conclusions:

  • Cellular polyploidy is a significant biological process with implications for tissue homeostasis.
  • Extensive polyploidy may contribute to organ failure.
  • Polyploidy can be a factor in oncogenesis, potentially activating precancerous clones.

Related Experiment Videos