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Drug-resistant tuberculosis in Turkish children
1Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey.
The Turkish Journal of Pediatrics
|August 11, 2000
Summary
This study found that 26.7% of pediatric tuberculosis patients had drug resistance. While streptomycin resistance was most common, resistance to other anti-tuberculosis drugs was generally low in this patient group.
Area of Science:
- Pediatric infectious diseases
- Antimicrobial resistance
- Public health
Background:
- Tuberculosis (TB) remains a significant global health challenge.
- Drug resistance in TB complicates treatment and increases transmission.
- Understanding pediatric drug resistance patterns is crucial for effective management.
Purpose of the Study:
- To determine the prevalence of anti-tuberculosis drug resistance in children.
- To identify specific drug resistance patterns in pediatric TB cases.
- To assess multidrug resistance in pediatric TB patients.
Main Methods:
- Retrospective search of 60 pediatric tuberculosis cases.
- Analysis of available drug susceptibility testing results.
- Calculation of resistance prevalence for individual drugs and multidrug resistance.
Main Results:
- Overall drug resistance was 26.7% in the studied pediatric population.
- Streptomycin (SM) resistance was the most frequent (18.3%).
- Resistance to isoniazid (6.7%), rifampicin (6.5%), and ethambutol (4.2%) was observed. Two cases (3.3%) showed multidrug resistance.
Conclusions:
- Anti-tuberculosis drug resistance, excluding streptomycin, was relatively low in pediatric patients at Hacettepe University.
- These findings highlight the importance of continued surveillance of drug resistance in pediatric TB.
- Further research may be needed to explore resistance trends and inform treatment guidelines.