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Drug-resistant tuberculosis in Turkish children
1Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Insights
This study found that 26.7% of pediatric tuberculosis patients had drug resistance. While streptomycin resistance was most common, resistance to other anti-tuberculosis drugs was generally low in this patient group.
Area of Science:
- Pediatric infectious diseases
- Antimicrobial resistance
- Public health
Background:
- Tuberculosis (TB) remains a significant global health challenge.
- Drug resistance in TB complicates treatment and increases transmission.
- Understanding pediatric drug resistance patterns is crucial for effective management.
Purpose of the Study:
- To determine the prevalence of anti-tuberculosis drug resistance in children.
- To identify specific drug resistance patterns in pediatric TB cases.
- To assess multidrug resistance in pediatric TB patients.
Main Methods:
- Retrospective search of 60 pediatric tuberculosis cases.
- Analysis of available drug susceptibility testing results.
- Calculation of resistance prevalence for individual drugs and multidrug resistance.
Main Results:
- Overall drug resistance was 26.7% in the studied pediatric population.
- Streptomycin (SM) resistance was the most frequent (18.3%).
- Resistance to isoniazid (6.7%), rifampicin (6.5%), and ethambutol (4.2%) was observed. Two cases (3.3%) showed multidrug resistance.
Conclusions:
- Anti-tuberculosis drug resistance, excluding streptomycin, was relatively low in pediatric patients at Hacettepe University.
- These findings highlight the importance of continued surveillance of drug resistance in pediatric TB.
- Further research may be needed to explore resistance trends and inform treatment guidelines.
Abstract:
The purpose of this study was to determine the prevalence of anti-tuberculosis drug resistance in children followed at Hacettepe University Ihsan Doğramaci Children's Hospital. Sixty cases with tuberculosis for whom susceptibility testing was available were searched retrospectively. Teh overall drug resistance was 26.7 percent. Resistance to streptomycin (sm) was the most frequent (18.3%), followed by isoniazid (6.7%), rifampicin (6.5%), and ethambutol (4.2%). Strain resistant to more than one drug was present in two cases (3.3%). In summary, excluding SM, both single and multidrug resistance were relatively low in our pediatric patients.