Related Experiment Video
Updated: Aug 15, 2026

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
Tests for linkage of multiple cohorts in an accelerated longitudinal design
1Department of Counseling, Educational Psychology, and Special Education, Michigan State University, Ann Arbor 48109, USA.
Abstract:
In accelerated longitudinal design, one samples multiple age cohorts and then collects longitudinal data on members of each cohort. The aim is to study age-outcome trajectories over a broad age span during a study of short duration. A threat to valid inference is the Age x Cohort interaction effect. S. W. Raudenbush and W. S. Chan (1993) developed a test for such interactions in the context of 2 cohorts by using a hierarchical model. The current article extends this approach to include any number of cohorts. Using the National Youth Survey, the authors combine data collected on 7 cohorts over 5 years to approximate change in antisocial attitudes between 11 and 21 years of age. They show how to test for cohort differences in trajectories, how to calculate the power of the test, and how to use graphical procedures to aid understanding. The approach allows unbalanced designs and the clustering of participants within families, neighborhoods, or other social units.
Related Concept Videos
Multiple Allele Traits
Longitudinal Research
Study Design in Statistics
Does aspirin reduce the risk of heart attacks? Is one brand of fertilizer more effective at growing roses than another? Is fatigue as dangerous to a driver as the influence of alcohol? Questions like these are answered using randomized experiments with proper...
Study Designs in Epidemiology
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and case-control studies.
Longitudinal Studies
Comparing the Survival Analysis of Two or More Groups
