Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Modelling transthoracic defibrillation waveforms.

V Krasteva1, A Cansell, I Daskalov

  • 1Centre of Biomedical Engineering, Bulgarian Academy of Sciences, Sofia, Bulgaria.

Journal of Medical Engineering & Technology
|August 11, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Electrochemotherapy of skin tumours: comparison of two electroporation protocols.

Journal of B.U.ON. : official journal of the Balkan Union of Oncology·2007
Same author

Electrochemotherapy of Mycosis fungoides by interferon-alpha.

Bioelectrochemistry (Amsterdam, Netherlands)·2006
Same author

[Electrical stimulation for rapid assessment of extremity tissues vitality in critical ischemia].

Annales de chirurgie·2004
Same author

Defibrillator-embedded rapid recovery electrocardiogram amplifier.

Journal of medical engineering & technology·2003
Same author

Automatic adjustment of chopping-modulated defibrillation pulses to patient transthoracic resistance.

Journal of medical engineering & technology·2003
Same author

[The future of electrical defibrillators for the heart].

Biomedizinische Technik. Biomedical engineering·2002

New research on implantable defibrillators advances understanding of heart electrophysiology. A simplified electrical model aids in developing and assessing efficient defibrillation pulse waveforms for improved cardiac treatment.

Area of Science:

  • Cardiovascular Electrophysiology
  • Biomedical Engineering
  • Medical Device Technology

Background:

  • Implantable defibrillators (ICDs) have spurred new insights into cardiac electrophysiology.
  • Existing models for defibrillation waveforms require reassessment and new approaches.
  • Understanding electrical impulse propagation is crucial for effective defibrillation.

Purpose of the Study:

  • To model the transmembrane voltage (Vm) response to various applied voltage (Vs) waveforms.
  • To develop a simplified electrical equivalent circuit for defibrillation modeling.
  • To establish criteria for efficient defibrillation pulse waveform design.

Main Methods:

  • Modeled transmembrane voltage (Vm) time course based on applied voltage (Vs) waveform shapes and amplitudes.

Related Experiment Videos

  • Represented excitable cell membrane impedance (Zm) with high resistance and low capacitance to avoid shunting effects.
  • Developed a simplified electrical equivalent circuit incorporating generator, electrode, and tissue resistances.

    • Main Results:

    • A highly simplified electrical equivalent circuit was achieved.
    • The model effectively predicted transmembrane voltage dynamics based on waveform characteristics.
    • Criteria for efficient defibrillation waveforms were proposed.

    Conclusions:

    • The proposed simplified circuit offers a straightforward method for modeling defibrillation pulses.
    • This approach facilitates the assessment and development of novel, efficient defibrillation waveforms.
    • The findings contribute to the advancement of cardiac electrophysiology and defibrillator technology.