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Efficient synthesis of 8-oxo-dGTP: a mutagenic nucleotide
1Amersham Pharmacia Biotech, Piscataway, NJ 08855, USA.
Bioorganic & Medicinal Chemistry Letters
|August 11, 2000
Abstract:
An efficient synthesis of mutagenic and oxidative DNA damage product, 8-oxo-dGTP (4) has been achieved in high yield, along with a serendipitous generation of 8-dimsyl-dG (2). In combination with dPTP (5), 8-oxo-dGTP (4) can be formulated into a kit for investigating DNA random mutagenesis.