Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Mitochondria in muscle cell death.

¹Department of Biomedical Sciences, University of Padova, Italy.

Italian Journal of Neurological Sciences

|August 11, 2000

Summary

Mitochondria play a critical role in cell death pathways, particularly in Duchenne

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Human neural stem cells derived from fetal human brain communicate with each other and rescue ischemic neuronal cells through tunneling nanotubes.

Cell death & disease·2024

Same author

Homogeneity assessment of the SuperCam calibration targets onboard rover perseverance.

Analytica chimica acta·2022

Same author

SuperCam Calibration Targets: Design and Development.

Space science reviews·2020

Same author

How the use of surgical masks during COVID-19 pandemic can induce skin effects.

Journal of the European Academy of Dermatology and Venereology : JEADV·2020

Same author

Pre-launch radiometric calibration of the infrared spectrometer onboard SuperCam for the Mars2020 rover.

The Review of scientific instruments·2020

Same author

CROCC-mutated rhabdoid colorectal carcinoma showing in intercellular spaces lamellipodia and cellular projections revealed by electron microscopy.

Virchows Archiv : an international journal of pathology·2019

Area of Science:

Mitochondrial biology and cell death.
Biochemistry and molecular biology.
Muscle cell physiology and disease.

Background:

Mitochondria are central to cellular energy production via oxidative phosphorylation.
Mitochondria critically regulate programmed cell death (apoptosis) through the release of specific proteins.
Mitochondrial dysfunction, including calcium dysregulation and oxidative stress, is implicated in Duchenne's muscular dystrophy pathogenesis.

Purpose of the Study:

To investigate the role of mitochondrial permeability transition in skeletal muscle cell death.
To validate bupivacaine's effects on mitochondrial depolarization and pore opening in a muscle cell toxicity model.
To explore therapeutic strategies targeting mitochondrial pathways in Duchenne's muscular dystrophy.

Main Methods:

Studying skeletal muscle mitochondria and the permeability transition pore.
Utilizing a short-term muscle cell toxicity model.
Investigating mitochondrial depolarization and pore opening as early events in cell death.

Main Results:

Mitochondrial permeability transition, modulated by cyclophilin D, is a key player in cell death.
Bupivacaine is being validated in a model of muscle cell toxicity.
Early events include mitochondrial depolarization and pore opening.

Conclusions:

Mitochondria are crucial targets in understanding and potentially treating muscle cell demise.
The permeability transition pore and cyclophilin D are significant factors in mitochondrial-mediated cell death.
Further research aims to develop drugs targeting these pathways for Duchenne's muscular dystrophy.

Related Experiment Videos