Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cardiovascular actions of python bradykinin and substance P in the anesthetized python, Python regius.

T Wang1, M Axelsson, J Jensen

  • 1School of Biological Sciences, University of Birmingham, Edgbaston, United Kingdom.

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
|August 12, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The hypothalamic satiety peptide CART is expressed in anorectic and non-anorectic pancreatic islet tumors and in the normal islet of Langerhans.

FEBS letters·1999
Same author

Pattern of injuries due to interpersonal violence.

Injury·1999
Same author

Early introduction of solid foods among urban African-American participants in WIC.

Journal of the American Dietetic Association·1999
Same author

Screening for somatization and hypochondriasis in primary care and neurological in-patients: a seven-item scale for hypochondriasis and somatization.

Journal of psychosomatic research·1999
Same author

The prevalence and etiology of impotence in 101 male hypertensive outpatients.

American journal of hypertension·1999
Same author

Pax6 and Cdx2/3 form a functional complex on the rat glucagon gene promoter G1-element.

FEBS letters·1999
Same journal

Changes in IMCL content and storage characteristics during an acute bout of high intensity interval exercise are influenced by sex and muscle fibre type.

American journal of physiology. Regulatory, integrative and comparative physiology·2026
Same journal

The Cardiorespiratory Response of Atlantic Salmon and Nile Tilapia to Similar Acute Thermal and Hypoxic Challenges: The Complete Story.

American journal of physiology. Regulatory, integrative and comparative physiology·2026
Same journal

Early Life Stress Blunts Time Of Day Specific Autonomic Function In Adult Male Mice.

American journal of physiology. Regulatory, integrative and comparative physiology·2026
Same journal

Homeostatic adaptations of the amphibious fish <i>Polypterus</i> in terrestrial environments.

American journal of physiology. Regulatory, integrative and comparative physiology·2026
Same journal

Renal Hemodynamic and Urinary Response to Baroreflex-Mediated Sympathetic Modulation: Insights from High-Resolution Arterial Impedance Analysis in Rats.

American journal of physiology. Regulatory, integrative and comparative physiology·2026
Same journal

Gravitational load, sex, and age-sex effects on cardiovascular compensatory responses during sit-to-stand and lie-to-stand transitions.

American journal of physiology. Regulatory, integrative and comparative physiology·2026
See all related articles

Bradykinin (BK) increases python blood pressure and heart rate by activating adrenergic neurons. Substance P (SP) lowers python blood pressure and resistance, suggesting kinins regulate python cardiovascular systems.

Area of Science:

  • Comparative physiology
  • Cardiovascular pharmacology
  • Herpetology

Background:

  • Bradykinin (BK) and Substance P (SP) are peptides with known physiological roles.
  • Their cardiovascular effects in reptiles, specifically snakes, are not well-characterized.
  • Understanding these roles can provide insights into reptilian cardiovascular regulation.

Purpose of the Study:

  • To investigate the cardiovascular actions of python bradykinin (BK) and substance P (SP) in the ball python (Python regius).
  • To elucidate the mechanisms underlying these cardiovascular responses, particularly the role of adrenergic pathways.

Main Methods:

  • Anesthetized ball pythons (Python regius) were used for intra-arterial injections.
  • Concentration-dependent effects of python BK and SP on blood pressure, heart rate, cardiac output, and systemic resistance were measured.

Related Experiment Videos

  • The involvement of adrenergic receptors was assessed using antagonists like sotalol and prazosin.

    • Main Results:

    • Python BK caused dose-dependent increases in blood pressure, heart rate, and cardiac output, with minor decreases in resistance and stroke volume.
    • BK administration significantly increased norepinephrine levels, suggesting adrenergic activation.
    • BK-induced effects were significantly attenuated by beta-adrenergic (sotalol) and alpha-adrenergic (prazosin) antagonists.
    • Python SP induced dose-dependent decreases in blood pressure and systemic resistance, with increases in cardiac output and stroke volume.
    • SP had minimal effects on heart rate.

    Conclusions:

    • Kinins, including BK and SP, play a significant role in cardiovascular regulation in pythons.
    • The cardiovascular effects of python BK are, in part, mediated by the activation of adrenergic neurons.
    • These findings highlight the conserved yet distinct roles of these peptides across vertebrateCardiovascular systems.