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UVA and UVB wavebands modulate expression of fasL in mouse skin epidermis
1Department of Veterinary Anatomy and Pathology, University of Sydney, New South Wales, Australia.
Redox Report : Communications in Free Radical Research
|August 12, 2000
Abstract:
In our previous report, we observed different cytokine modulation in mouse epidermis by the UVA and UVB wavebands. In the present investigations, the effects of irradiation with UVA and UVB on the Fas(CD95)/FasL system have been studied because apoptosis mediated by the interaction between Fas and FasL has been suggested recently to be associated with UVB-induced immunosuppression in mouse skin. Our results show that UVA irradiation following UVB irradiation has the ability to reduce the up-regulation of FasL expression in mouse skin resulting from the UVB irradiation.