Related Experiment Video
Updated: Oct 13, 2026

Culturing Mammalian Cells in Three-dimensional Peptide Scaffolds
Published on: June 13, 2018
Extracellular matrix cell adhesion peptides: functional applications in orthopedic materials
1Laboratory of Extracellular Matrix and Cell Adhesion Research, Division of Life Sciences, The University of Texas at San Antonio, San Antonio, Texas, USA.
Abstract:
This review describes research on selected peptide sequences that affect cell adhesion as it applies in orthopedic applications. Of particular interest are the integrin-binding RGD peptides and heparin-binding peptides. The influence of these peptides on cell adhesion is described. Cell adhesion is defined as a sequence of four steps: cell attachment, cell spreading, organization of an actin cytoskeleton, and formation of focal adhesions. RGD sequences clearly influence cell attachment and spreading, whereas heparin-binding sequences appear to be less efficient. Collectively, these sequences appear to promote all steps of cell adhesion in certain cell types. This review also addresses issues related to peptide immobilization, as well as potential complexities that may develop as a result of using these versatile cell-binding sequences. Also described are future directions in the field concerning use of existing and more sophisticated peptide substrata.
More Related Videos
06:15Wet Chemistry and Peptide Immobilization on Polytetrafluoroethylene for Improved Cell-adhesion
Published on: August 15, 2016
09:11Using Cell-substrate Impedance and Live Cell Imaging to Measure Real-time Changes in Cellular Adhesion and De-adhesion Induced by Matrix Modification
Published on: February 19, 2015
Related Concept Videos
Overview of Cell-Matrix Interactions
The Extracellular Matrix
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
The Extracellular Matrix
Extracellular Matrix
Cell-matrix's Response to Mechanical Forces
Anchoring junctions mechanically attach a cell to the...
Matrix Proteoglycans and Glycoproteins