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Related Experiment Videos

Regional lymph node dissections in malignant melanoma.

G P Lawton1, S Ariyan

  • 1Yale Melanoma Unit, Department of Surgery, Yale University School of Medicine, New Haven, Connecticut, USA.

Clinics in Plastic Surgery
|August 15, 2000
PubMed
Summary
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Elective lymph node dissection (ELND) is recommended for melanoma patients with primary tumors at least 1.0 mm thick. This approach is based on identifying metastatic cells in the sentinel lymph node, improving patient selection for this procedure.

Area of Science:

  • Oncology
  • Dermatology
  • Surgical Pathology

Background:

  • Controversy exists regarding regional lymphadenectomy for cutaneous melanoma with clinically negative nodes.
  • Therapeutic lymph node dissection offers clear benefits for patients with clinically positive nodes.
  • Elective lymph node dissection (ELND) for clinically negative nodes is debated due to the high rate (80%) of histologically negative nodes in Stage I disease.

Purpose of the Study:

  • To evaluate the role of sentinel lymph node dissection in selecting patients for elective lymph node dissection (ELND) in cutaneous melanoma.
  • To provide a recommendation for the application of ELND based on sentinel lymph node status.

Main Methods:

  • Sentinel lymph node dissection (SLND) to identify patients likely to benefit from further nodal intervention.

Related Experiment Videos

  • Analysis of patient cohorts undergoing SLND for primary melanomas.

    • Main Results:

    • Sentinel lymph node dissection allows for the selection of patients who may benefit from elective lymph node dissection (ELND).
    • Identification of metastatic cells in the sentinel lymph node is a key factor for recommending ELND.

    Conclusions:

    • The authors recommend elective lymph node dissection (ELND) for patients with primary melanomas of at least 1.0 mm thickness.
    • ELND is recommended when metastatic cells are identified within the sentinel lymph node, optimizing treatment for melanoma patients.