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Evaluation of zuclopenthixol acetate to decrease handling stress in wapiti.

M Read1, N Caulkett, M McCallister

  • 1Department of Veterinary Anesthesiology, Radiology and Surgery, Western College of Veterinary Medicine, Saskatoon, Saskatchewon, Canada. matt.read@usask.ca

Journal of Wildlife Diseases
|August 15, 2000
PubMed
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Long-acting neuroleptic drugs, like zuclopenthixol acetate (Clopixol-Acuphase), effectively reduce handling stress and activity in North American elk (wapiti). This study demonstrated significant physiological improvements in treated animals compared to controls.

Area of Science:

  • Wildlife Management
  • Veterinary Pharmacology
  • Animal Physiology

Background:

  • Intensive management of wildlife frequently leads to stress and capture myopathy.
  • Long-acting neuroleptic (LAN) drugs are increasingly used to mitigate capture-related stress in wildlife.
  • Limited data exists on LAN drug efficacy in North American wildlife species.

Purpose of the Study:

  • To evaluate the efficacy of zuclopenthixol acetate (Clopixol-Acuphase) in reducing stress and activity in wild wapiti (North American elk).
  • To assess quantifiable and subjective measures of stress and activity post-administration.

Main Methods:

  • A blinded, randomized study involving 11 wapiti treated with Clopixol-Acuphase and 12 controls.
  • Measurements included body temperature, hemoconcentration, serum cortisol, blood lactate, and acid-base balance.

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  • Evaluations were conducted 24 and 72 hours after drug administration.

    • Main Results:

    • Treated wapiti showed significantly lower body temperatures, hemoconcentration, serum cortisol, and blood lactate levels at 24 hours.
    • Reduced metabolic acidosis was observed in treated animals compared to controls.
    • Control animals exhibited elevated creatine phosphokinase, indicative of muscle damage, while treated animals did not.

    Conclusions:

    • Zuclopenthixol acetate (Clopixol-Acuphase) effectively decreases quantifiable stress and activity in wapiti during handling.
    • The drug's beneficial effects were measurable up to 72 hours post-administration.
    • Clopixol-Acuphase is a valuable tool for managing handling stress in wapiti, preventing capture myopathy.