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Cellular transplants as sources for therapeutic agents.
P A Tresco1, R Biran, M D Noble
1Department of Bioengineering, The Keck Center for Tissue Engineering, The Huntsman Cancer Institute, Tissue Engineering Laboratory, University of Utah, 20 South 2030 East, Room 506, 84112 9458, Salt Lake City, UT, USA. patrick.tresco@m.cc.utah.edu
Advanced Drug Delivery Reviews
|August 16, 2000
Summary
Transplanted cells offer a novel approach for delivering therapeutic proteins, overcoming challenges in conventional drug delivery. This method leverages genetic and tissue engineering for future medical applications.
Area of Science:
- Biotechnology and Regenerative Medicine
- Cell-based Therapeutics
- Drug Delivery Systems
Background:
- Soluble factors from human cells are crucial therapeutic agents.
- Conventional delivery of protein-based therapeutics faces significant challenges.
- Limited clinical translation of cell-derived therapeutics exists.
Purpose of the Study:
- To review transplanted cells as an alternative drug delivery system.
- To explore the complexities and challenges of cell-based drug delivery.
- To discuss the role of engineering and developmental biology in this field.
Main Methods:
- Review of current literature on cell transplantation for therapeutic protein delivery.
- Analysis of genetic engineering, tissue engineering, and developmental biology principles.
- Focus on neuro/endocrine applications.
Main Results:
- Transplanted cells present a viable alternative to conventional delivery systems.
- Integration of genetic and tissue engineering is key to developing this field.
- Neuro/endocrine applications show particular promise.
Conclusions:
- Cell-based delivery requires further development for clinical practice.
- Key components are identified to advance transplanted cell therapies.
- Future developments aim to bridge the gap between research and medical application.