Brugada-type electrocardiographic pattern induced by cocaine
L Littmann1, M H Monroe, R H Svenson
1Department of Internal Medicine, Carolinas Medical Center, Charlotte, NC 28232, USA.
Mayo Clinic Proceedings
|August 16, 2000
Summary
Cocaine use can trigger a Brugada pattern, an electrocardiogram (ECG) abnormality, in susceptible individuals. The long-term clinical significance of this cocaine-induced ECG change remains undetermined.
Area of Science:
- Cardiology
- Electrophysiology
- Pharmacology
Background:
- Brugada syndrome is characterized by a specific electrocardiogram (ECG) pattern, featuring right bundle branch block and ST-segment elevation in leads V1-V3.
- This ECG pattern is associated with an increased risk of sudden cardiac death.
Observation:
- A case study of a young, healthy male who exhibited a transient Brugada pattern on ECG.
- This abnormal ECG pattern was repeatedly observed following recreational cocaine use.
- Attempts to reproduce the Brugada sign using procainamide, propranolol, and noradrenaline were unsuccessful.
Findings:
- Electrophysiologic study in the presence of the Brugada ECG pattern did not induce any arrhythmias.
- Cocaine use was identified as a potential trigger for the Brugada sign in this individual.
- The study highlights a potential link between recreational drug use and ECG abnormalities.
Implications:
- Cocaine may unmask or provoke the Brugada sign in individuals with underlying susceptibility.
- Further research is needed to understand the clinical significance and long-term consequences of cocaine-induced Brugada patterns.
- This case underscores the importance of considering substance use when evaluating unexplained ECG abnormalities.
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