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Related Experiment Videos

Brugada-type electrocardiographic pattern induced by cocaine.

L Littmann1, M H Monroe, R H Svenson

  • 1Department of Internal Medicine, Carolinas Medical Center, Charlotte, NC 28232, USA.

Mayo Clinic Proceedings
|August 16, 2000
PubMed
Summary

Cocaine use can trigger a Brugada pattern, an electrocardiogram (ECG) abnormality, in susceptible individuals. The long-term clinical significance of this cocaine-induced ECG change remains undetermined.

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Area of Science:

  • Cardiology
  • Electrophysiology
  • Pharmacology

Background:

  • Brugada syndrome is characterized by a specific electrocardiogram (ECG) pattern, featuring right bundle branch block and ST-segment elevation in leads V1-V3.
  • This ECG pattern is associated with an increased risk of sudden cardiac death.

Observation:

  • A case study of a young, healthy male who exhibited a transient Brugada pattern on ECG.
  • This abnormal ECG pattern was repeatedly observed following recreational cocaine use.
  • Attempts to reproduce the Brugada sign using procainamide, propranolol, and noradrenaline were unsuccessful.

Findings:

  • Electrophysiologic study in the presence of the Brugada ECG pattern did not induce any arrhythmias.
  • Cocaine use was identified as a potential trigger for the Brugada sign in this individual.

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  • The study highlights a potential link between recreational drug use and ECG abnormalities.

    • Implications:

    • Cocaine may unmask or provoke the Brugada sign in individuals with underlying susceptibility.
    • Further research is needed to understand the clinical significance and long-term consequences of cocaine-induced Brugada patterns.
    • This case underscores the importance of considering substance use when evaluating unexplained ECG abnormalities.