Related Experiment Video
Updated: Aug 7, 2026

Detection of In Situ Protein-protein Complexes at the Drosophila Larval Neuromuscular Junction Using Proximity Ligation Assay
Published on: January 20, 2015
Drosophila dumbfounded: a myoblast attractant essential for fusion
M Ruiz-Gómez1, N Coutts, A Price
1Department of Zoology, University of Cambridge, United Kingdom. mruiz@cbm.uam.es
Abstract:
Aggregation and fusion of myoblasts to form myotubes is essential for myogenesis in many organisms. In Drosophila the formation of syncytial myotubes is seeded by founder myoblasts. Founders fuse with clusters of fusion-competent myoblasts. Here we identify the gene dumbfounded (duf) and show that it is required for myoblast aggregation and fusion. duf encodes a member of the immunoglobulin superfamily of proteins that is an attractant for fusion-competent myoblasts. It is expressed by founder cells and serves to attract clusters of myoblasts from which myotubes form by fusion.
More Related Videos
08:43Detergent-assisted Reconstitution of Recombinant Drosophila Atlastin into Liposomes for Lipid-mixing Assays
Published on: July 3, 2019
07:26A GFP Complementation-based Dual-expression System for Assessing Cell-Cell Contact Mediated by Cytonemes in Live Drosophila Wing Imaginal Discs
Published on: August 22, 2025
Related Concept Videos
Intermolecular Forces
Valence Bond Theory
Membrane Fluidity
Mosaic nature of the membrane
The mosaic characteristic of the membrane helps the plasma membrane remain fluid. The integral proteins and lipids exist as separate but loosely-attached molecules in the membrane. The membrane is a relatively...
Diamagnetic Shielding of Nuclei: Local Diamagnetic Current
Nuclear Overhauser Enhancement (NOE)
Diversity of Protists III