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Related Experiment Videos

Multi-analyte interrogation using the fiber optic biosensor.

G P Anderson1, K D King, K L Gaffney

  • 1Naval Research Laboratory, Center for Bio/Molecular Science and Engineering, Washington, DC 20375-5438, USA. ganderson@cbmse.nrl.navy.mil

Biosensors & Bioelectronics
|August 17, 2000
PubMed
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The portable RAPTOR biosensor can simultaneously detect four different biological targets in field samples. This automated fiber optic device offers rapid fluoroimmunoassays with adjustable assay times for efficient threat detection.

Area of Science:

  • Biotechnology
  • Biosensor Technology
  • Field Detection

Background:

  • The need for rapid, on-site detection of biological agents is critical for security and public health.
  • Existing methods often require laboratory analysis, delaying results.
  • Automated, portable biosensors offer a solution for field-based diagnostics.

Purpose of the Study:

  • To evaluate the capabilities of the RAPTOR (Rapid Automated Portable TOol for analysis and Reporting) fiber optic biosensor.
  • To assess its performance in detecting multiple biological targets simultaneously in field conditions.
  • To determine the sensitivity and assay times for various analytes.

Main Methods:

  • The RAPTOR biosensor, designed for rapid fluoroimmunoassays, was utilized.

Related Experiment Videos

  • The device was configured to test for up to four different target analytes concurrently.
  • A total of 203 blind samples were tested for Staphylococcal enterotoxin B, ricin, Francisella tularensis, and Bacillus globigii.
  • Assay times were varied between a 3-minute rapid screen and a 10-minute standard test.

    • Main Results:

    • The RAPTOR biosensor demonstrated the ability to perform simultaneous detection of multiple analytes.
    • Sensitivities achieved were 10 ng/ml for Staphylococcal enterotoxin B, 50 ng/ml for ricin, 5 x 10(5) cfu/ml for Francisella tularensis, and 5 x 10(4) cfu/ml for Bacillus globigii.
    • Assay times were successfully adjusted from 3 to 10 minutes.

    Conclusions:

    • The portable, automated RAPTOR biosensor is effective for rapid, simultaneous detection of biological agents in field settings.
    • The device offers flexible assay times, enhancing its utility for diverse operational needs.
    • The evaluated sensitivities indicate its potential for early and accurate identification of specific threats.