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Array biosensor for detection of biohazards.

C A Rowe-Taitt1, J P Golden, M J Feldstein

  • 1Center for Bio/Molecular Science and Engineering, Naval Research Laboratory, Washington, DC 20375-5348, USA.

Biosensors & Bioelectronics
|August 17, 2000
PubMed
Summary
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A novel fluorescence biosensor enables simultaneous detection of multiple biohazardous agents, including toxins and bacteria. This rapid array biosensor offers sensitive detection in the ng/ml and cfu/ml ranges.

Area of Science:

  • Biotechnology
  • Analytical Chemistry
  • Immunosensing

Background:

  • Detection of biohazardous agents is critical for public health and security.
  • Existing methods for simultaneous detection are often complex and time-consuming.

Purpose of the Study:

  • To develop a fluorescence-based biosensor for simultaneous, sensitive, and rapid detection of multiple biohazardous agents.
  • To create an array biosensor utilizing antibody-functionalized planar waveguides.

Main Methods:

  • Immobilization of antibodies on a planar waveguide surface to capture antigens.
  • Quantification of bound analyte using fluorescent tracer antibodies.
  • Detection and analysis of fluorescent signals with a CCD camera and image analysis software.

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Main Results:

  • Simultaneous detection of toxins, toxoids, and bacterial strains was achieved.
  • Achieved limits of detection in the mid-ng/ml range for toxins/toxoids and 10(3)-10(6) cfu/ml for bacteria.
  • Developed an automated system for staphylococcal enterotoxin B (SEB) detection in the low ng/ml range.

Conclusions:

  • The developed array biosensor provides a sensitive and efficient platform for multiplexed detection of biohazardous agents.
  • The system demonstrates potential for rapid screening and diagnostics in various applications.
  • Further development of automated fluidics and imaging enhances practical usability.