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Cholesteryl ester transfer protein and atherosclerosis.
A Inazu1, J Koizumi, H Mabuchi
1Second Department of Internal Medicine, School of Medicine, Kanazawa University, Japan. inazua@mhs.mp.kanazawa-u.ac.jp
Current Opinion in Lipidology
|August 17, 2000
Summary
Cholesteryl ester transfer protein (CETP) moves cholesteryl esters between lipoproteins. CETP may promote atherosclerosis in conditions like hypercholesterolemia, suggesting it as a potential therapeutic target.
Area of Science:
- Biochemistry
- Cardiovascular Science
- Human Genetics
Background:
- Plasma cholesteryl ester transfer protein (CETP) mediates lipid transfer between lipoproteins.
- CETP's role in atherosclerosis is complex and debated.
- Genetic variations in CETP influence its function and association with cardiovascular disease.
Purpose of the Study:
- To review human plasma CETP research, focusing on genetic polymorphisms.
- To elucidate the dual role of CETP in atherosclerosis based on metabolic context.
- To evaluate CETP as a potential therapeutic target for atherosclerosis.
Main Methods:
- Review of human population genetics studies.
- Analysis of transgenic mouse models.
- Examination of specific CETP polymorphisms: TaqIB, 1405V, and D442G.
Main Results:
- CETP genetic variations (TaqIB, 1405V, D442G) are associated with altered lipid profiles.
- CETP exhibits a dual effect on atherosclerosis, influenced by the patient's metabolic state.
- In hypercholesterolemia and combined hyperlipidemia, CETP appears pro-atherogenic.
Conclusions:
- Plasma CETP's impact on atherosclerosis is context-dependent.
- CETP may be a viable therapeutic target in specific dyslipidemic conditions.
- Further research into CETP modulation could offer new avenues for atherosclerosis treatment.