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Effect of DL-alpha-lipoic acid on tissue nucleic acid contents in aged rats
P Arivazhagan1, C Panneerselvam
1Department of Medical Biochemistry, Dr AL Mudaliar Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600113, India.
Abstract:
We have attempted to evaluate the effect of DL-alpha-lipoic acid on nucleic acid and protein contents in young and aged rats. An age-associated decrease in the deoxyribonucleic acid (DNA), ribonucleic acid (RNA) and protein contents were observed in aged rats. DL-alpha-lipoic acid was administered intraperitoneally (100 mg/kg body weight/day) to young and aged rats from 7 and 14 days. Lipoate administration demonstrated a substantial increase in nucleic acid and protein contents in aged rats. Hence it can be justified that lipoate is functionally efficient in helping the cell to recover from oxidative damage.