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[Association of polymorphic variants of serotonin neurotransmitter system genes with the recurrent dorsalgia in
S Yu Tereshchenko1, K V Afonicheva1, M V Shubina1
1Krasnoyarsk Science Center of the Siberian Branch of the Russian Academy of Sciences - Research Institute of Medical Problems of the North, Krasnoyarsk, Russia.
Objective:
To analyze the association between polymorphic variants of genes within the serotonergic system to elucidate their potential candidate role in the development of recurrent dorsalgia among adolescents.
Material And Methods:
The study population consisted of Caucasian adolescents aged 12 to 18 years (n=817; mean age 14.38±1.92 years, boy/girl ratio - 45.4%/54.6%). The characteristics of recurrent dorsalgia were assessed in these adolescents, and saliva samples were collected for subsequent DNA isolation and genotyping of gene polymorphisms.
Results:
The findings indicate that the G allele of HTR1A rs6295 is protective against the severe pain in adolescents with recurrent dorsalgia. Conversely, the T rs6311 allele of the HTR2A gene and the A rs1799913 allele of the TPH1 gene were associated with an elevated risk of severe pain in this population.
Conclusions:
The results align with contemporary models of the role of the serotonergic system in mechanisms underlying the perception and tolerance of pain stimuli.
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