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Updated: Aug 17, 2026
Optimized Protocols for Mycobacterium leprae Strain Management: Frozen Stock Preservation and Maintenance in Athymic Nude Mice
Published on: March 23, 2014
Role of inducible nitric oxide synthase in resistance to Mycobacterium leprae in mice
L B Adams1, C K Job, J L Krahenbuhl
1National Hansen's Disease Programs, Laboratory Research Branch at Louisiana State University, Baton Rouge, Louisiana 70894, USA. ladams1@lsu.edu
Abstract:
The manifestation of leprosy in humans is largely determined by host immunity to Mycobacterium leprae and is a model for immunoregulation in a human disease. However, animal models available for exploration of the leprosy spectrum are inadequate. This study explored M. leprae infection in mice deficient in inducible nitric oxide synthase, and this report describes elements resembling borderline tuberculoid leprosy in humans.
