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A brief history of the randomized controlled trial. From oranges and lemons to the gold standard
1Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA.
Hematology/Oncology Clinics of North America
|August 19, 2000
Abstract:
This article discusses the history and development of randomized clinical trial methodology, the reasons for its status and authority as a method of therapeutic evaluation, and the continuing role of clinical judgement in designing, interpreting, and applying the findings of trials.