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Urinary incontinence: an unrecognised adverse effect with donepezil
Lancet (London, England)
|August 19, 2000
Summary
Donepezil, used in Japan since 1999 for cognitive function, was studied in 94 Alzheimer's patients. Seven patients experienced transient urinary incontinence as a side effect.
Area of Science:
- Neuroscience
- Pharmacology
Background:
- Donepezil is a centrally acting acetylcholinesterase inhibitor.
- It has been approved in Japan since 1999 for improving cognitive function in Alzheimer's disease patients.
Discussion:
- Urinary incontinence is a potential adverse effect of donepezil treatment.
- This side effect appears to be transient in most cases.
Key Insights:
- A study of 94 Alzheimer's disease patients treated with donepezil revealed a 7.4% incidence of urinary incontinence.
- The onset of incontinence was generally temporary, suggesting a manageable side effect profile.
Outlook:
- Further research may explore the mechanisms underlying donepezil-induced urinary incontinence.
- Monitoring for and managing this side effect could be important in clinical practice.
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