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Related Experiment Videos

Salmeterol in paediatric asthma.

C Byrnes1, S Shrewsbury, P J Barnes

  • 1Department of Paediatrics, Imperial School of Medicine at the National Heart and Lung Institute, London, UK.

Thorax
|August 19, 2000
PubMed
Summary
This summary is machine-generated.

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Salmeterol, a long-acting inhaled beta-agonist, significantly improved morning peak expiratory flow (PEF) in children with asthma compared to salbutamol. Both 50mcg and 100mcg doses of salmeterol were effective, with no significant difference between them.

Area of Science:

  • Pediatric Pulmonology
  • Pharmacology
  • Asthma Management

Background:

  • British guidelines recommend long-acting inhaled beta(2) agonists at step 3 for asthma.
  • Previous studies questioned their additional benefit in pediatric asthma patients.

Purpose of the Study:

  • To compare the efficacy of salmeterol (50mcg bd, 100mcg bd) versus salbutamol (200mcg qds) in symptomatic children with asthma on inhaled corticosteroids.
  • To evaluate effects on symptom scores, peak expiratory flow (PEF), rescue medication use, spirometry, and bronchial hyperreactivity.

Main Methods:

  • Double-blind, three-way crossover study.
  • Involved 45 children (5-14 years) with moderate to severe asthma on inhaled corticosteroids (≥400mcg/day).
  • Treatments administered over one-month periods.

Related Experiment Videos

Main Results:

  • All treatments improved asthma control, morning/evening PEF, and spirometric indices.
  • Mean morning PEF was significantly higher with salmeterol (50mcg and 100mcg) compared to salbutamol.
  • No significant difference in efficacy was found between the two salmeterol doses; all treatments were well-tolerated.

Conclusions:

  • Salmeterol (50mcg bd or 100mcg bd) is more effective than salbutamol (200mcg qds) for improving morning PEF in children with moderate to severe asthma on inhaled corticosteroids.
  • The 100mcg dose of salmeterol may be considered for children remaining symptomatic on the 50mcg dose.