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[Hormonal profile in men with premature androgenic alopecia]
Abstract:
Androgenetic alopecia especially that with premature onset can be a cause of serious psychic trauma. As far as the treatment with antiandrogens, inhibitors of 5 alpha-reductase or hair transplantation represents a heavy economic burden for the patient, we tried to exclude other hormonal causes or to find a criterion for the apt candidates for the treatment in 15 young men with premature androgenetic alopecia. Hormonal analysis discovered a significantly lower plasma level of sexual binding globulin (SHBG) and FSH and nearly significantly higher concentration of 17 alpha-hydroxyprogesterone. These data resemble those in the hormonal pattern of women suffering from the syndrome of polycystic ovaries (PCOS). The finding of premature balding as the possible male phenotype hormonal equivalent of polycystic ovaries is in concordance with several pedigree studies in kindreds with PCOS, which have suggested a genetic basis of this syndrome in some families in which balding and pilosity was frequent in male members.
Insights
Premature androgenetic alopecia in men may indicate hormonal imbalances similar to polycystic ovary syndrome (PCOS). This finding could help identify suitable candidates for hair loss treatments.
Area of Science:
- Endocrinology
- Dermatology
- Genetics
Context:
- Premature androgenetic alopecia (male pattern baldness) can cause significant psychological distress.
- Current treatments like antiandrogens, 5 alpha-reductase inhibitors, and hair transplantation are costly.
- Identifying specific hormonal markers could aid in selecting appropriate candidates for treatment.
Purpose:
- To investigate hormonal profiles in young men with premature androgenetic alopecia.
- To explore potential links between male pattern baldness and hormonal patterns seen in Polycystic Ovary Syndrome (PCOS).
Summary:
- Hormonal analysis in 15 young men with premature androgenetic alopecia revealed significantly lower plasma levels of sex hormone-binding globulin (SHBG) and follicle-stimulating hormone (FSH).
- A nearly significant increase in 17 alpha-hydroxyprogesterone concentration was also observed.
- These hormonal findings mirror those in women with PCOS, suggesting a potential male hormonal equivalent.
Impact:
- Premature balding might serve as a male phenotype indicator for conditions like PCOS.
- This research aligns with genetic studies suggesting a familial basis for PCOS, where balding is common in affected males.
- Findings could lead to more targeted diagnostic approaches and treatments for male hair loss.