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Updated: Aug 10, 2026

Assessment of Pulmonary Capillary Blood Volume, Membrane Diffusing Capacity, and Intrapulmonary Arteriovenous Anastomoses During Exercise
Published on: February 20, 2017
Test and evaluation of exercise-enhanced preoxygenation in U-2 operations
T C Hankins1, J T Webb, G C Neddo
19th Medical Operations Squadron, Beale AFB, CA 95903, USA. thomas.hankins@beale.af.mil
Exercise during preoxygenation can prevent decompression sickness (DCS) for U-2 pilots. This method improves denitrogenation, enhancing flight safety without increasing preoxygenation time.
Area of Science:
- Aerospace Medicine
- Physiology
- Aviation Safety
Background:
- Preoxygenation is crucial for preventing decompression sickness (DCS) during high-altitude U-2 flights.
- Standard preoxygenation protocols are time-consuming and may not always ensure adequate protection.
- Enhancing denitrogenation through exercise during preoxygenation is a potential strategy to improve DCS prevention.
Observation:
- A U-2 pilot experiencing DCS volunteered for exercise-enhanced preoxygenation.
- The pilot performed 10 minutes of strenuous exercise during preoxygenation before high-altitude flights.
- This intervention was implemented without extending the total preoxygenation duration.
Findings:
- The pilot completed 36 subsequent high-altitude flights with no reported DCS incidents.
- Exercise was performed at approximately 75% of maximal oxygen uptake, monitored by heart rate.
- This operational test demonstrated a statistically significant reduction in DCS occurrences.
Implications:
- Exercise-enhanced preoxygenation offers a viable method to reduce DCS risk in susceptible U-2 pilots.
- Further data collection from the U-2 pilot population is recommended for broader implementation.
- This approach reinforces laboratory findings and suggests a practical improvement for aviation safety protocols.
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