Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pavlov and integrative physiology.

G P Smith1

  • 1Department of Psychiatry, Joan and Sanford I. Weill Medical College of Cornell University and E. W. Bourne Laboratory, New York-Presbyterian Hospital, Westchester Division, White Plains, New York 10605, USA. gpsmith@mail.med.cornell.edu

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
|August 24, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cutaneous manifestations of small fibre polyneuropathy.

Journal of the European Academy of Dermatology and Venereology : JEADV·2021
Same author

Analysis of US Food and Drug Administration Warning Letters within dermatological care products.

Clinical and experimental dermatology·2021
Same author

Evaluation of malignancy risk in scleroderma by antibody profile.

The British journal of dermatology·2020
Same author

Analysis of the first 5 years of an interdisciplinary Rheumatology-Dermatology clinic.

Clinical and experimental dermatology·2020
Same author

Development of an auxotrophic, live-attenuated Brucella suis vaccine strain capable of expressing multimeric GnRH.

Vaccine·2019
Same author

Mycobacterium tuberculosis and whole-genome sequencing: how close are we to unleashing its full potential?

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2017
Same journal

Changes in IMCL content and storage characteristics during an acute bout of high intensity interval exercise are influenced by sex and muscle fibre type.

American journal of physiology. Regulatory, integrative and comparative physiology·2026
Same journal

The Cardiorespiratory Response of Atlantic Salmon and Nile Tilapia to Similar Acute Thermal and Hypoxic Challenges: The Complete Story.

American journal of physiology. Regulatory, integrative and comparative physiology·2026
Same journal

Early Life Stress Blunts Time Of Day Specific Autonomic Function In Adult Male Mice.

American journal of physiology. Regulatory, integrative and comparative physiology·2026
Same journal

Homeostatic adaptations of the amphibious fish <i>Polypterus</i> in terrestrial environments.

American journal of physiology. Regulatory, integrative and comparative physiology·2026
Same journal

Renal Hemodynamic and Urinary Response to Baroreflex-Mediated Sympathetic Modulation: Insights from High-Resolution Arterial Impedance Analysis in Rats.

American journal of physiology. Regulatory, integrative and comparative physiology·2026
Same journal

Gravitational load, sex, and age-sex effects on cardiovascular compensatory responses during sit-to-stand and lie-to-stand transitions.

American journal of physiology. Regulatory, integrative and comparative physiology·2026
See all related articles

Ivan Pavlov pioneered integrative physiology by developing chronic experimental methods in unanesthetized animals. His Nobel Prize-winning research on digestive secretions revolutionized physiological studies.

Area of Science:

  • Physiology
  • Neuroscience
  • Medical Research

Background:

  • Ivan Pavlov, the first physiologist to win a Nobel Prize, was awarded the honor in 1904.
  • His research focused on the neural control of digestive secretions, including salivary, gastric, and pancreatic functions.

Discussion:

  • Pavlov's innovative use of chronic, unanesthetized animal models with surgical fistulas allowed for repeated, long-term experiments.
  • This methodological advancement overcame limitations of acute, anesthetized animal studies, establishing a new standard in physiological research.
  • His work laid the foundation for modern integrative physiology, emphasizing the study of complex biological systems over time.

Key Insights:

  • The development of chronic surgical techniques in animal models was crucial for Pavlov's success.

Related Experiment Videos

  • Pavlov's research demonstrated the neural mechanisms governing digestive processes.
  • His approach facilitated a deeper understanding of physiological systems through repeated observations in the same subject.

    • Outlook:

    • Pavlov's methods continue to influence experimental design in physiology and related fields.
    • His legacy underscores the importance of methodological innovation in scientific discovery.
    • The paper explores Pavlov's journey and his perspectives on the interplay between physiology and clinical medicine.