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Bronchial hyperreactivity is associated with enhanced grain dust-induced airflow obstruction
J N Kline1, P J Jagielo, J L Watt
1Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA. joel-kline@uiowa.edu
Journal of Applied Physiology (Bethesda, Md. : 1985)
|August 24, 2000
Abstract:
Bronchial hyperreactivity (BHR) is associated with the presence of airway inflammation in asthma and is seen in individuals occupationally exposed to grain dust. To better understand the relationship between BHR and pulmonary inflammation after grain dust exposure, we carried out an inhalation challenge to corn dust extract (CDE) on seven subjects with BHR [a 20% or greater decrease in forced expiratory volume in 1 s (FEV(1)) compared with diluent FEV(1) with a cumulative dose of histamine