Cerebrospinal fluid formation in ventricles and spinal subarachnoid space of the rhesus monkey

The authors perfused rhesus monkeys from lateral ventricles to lumbar sac with an artificial cerebrospinal fluid (CSF) containing a Blue Dextran 2000 marker. Analysis of marker dilution at steady state showed ventricular CSF formation occurring at a rate of 28.3 plus or minus mu1/min. No significant CSF formation was found in the spinal subarachnoid space.