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Updated: Aug 30, 2026

Preparation and Culture of Myogenic Precursor Cells/Primary Myoblasts from Skeletal Muscle of Adult and Aged Humans
Published on: February 16, 2017
Age-related changes in muscle
1Division of Endocrinology, Metabolism, Nutrition, and Internal Medicine, Mayo Clinic Rochester, Minn., USA.
Abstract:
Sarcopenia is a debilitating condition that occurs with senescence. The present study places this entity in the context of life expectancy, then discusses the mechanism of muscle loss. The findings show deficits in muscle protein synthesis with advancing age and suggest that these deficits are specific to certain muscle protein components. Synthesis rates of myosin heavy chain and mitochondrial protein decline with advancing age; however, there are no specific conclusions as to causation of these reduced muscle protein syntheses. The utility of protein dynamic measurements in evaluating potential therapies is discussed.
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