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Leukocyte recruitment during pulmonary Cryptococcus neoformans infection
G B Huffnagle1, T R Traynor, R A McDonald
1Pulmonary Division, University of Michigan Medical School, Ann Arbor, MI 48109-0642, USA. ghuff@umich.edu
Immunopharmacology
|August 29, 2000
Summary
Chemokines like MCP-1 and MIP-1alpha mediate leukocyte recruitment for clearing Cryptococcus neoformans. Receptor knockout studies show CCR2 and CCR5 are vital for immune response and innate immunity.
Area of Science:
- Immunology
- Microbiology
- Infectious Diseases
Background:
- Leukocyte recruitment is crucial for controlling Cryptococcus neoformans infections.
- Chemokines play a significant role in directing immune cell migration to infection sites.
Purpose of the Study:
- To review the role of CC chemokines in leukocyte recruitment during Cryptococcus neoformans infection.
- To highlight the importance of chemokine receptors CCR2 and CCR5 in the innate immune response.
Main Methods:
- Review of laboratory data on chemokine function.
- Analysis of studies involving CC chemokine receptor knockout mice.
Main Results:
- CC chemokines, including MCP-1 and MIP-1alpha, are key mediators of leukocyte recruitment.
- CCR2 and CCR5 are essential for effective leukocyte recruitment.
- CCR2 and CCR5 are also critical for immune response development and innate immunity against C. neoformans.
Conclusions:
- Chemokines and their receptors are central to the host defense against Cryptococcus neoformans.
- Targeting CCR2 and CCR5 pathways may offer therapeutic strategies for cryptococcosis.