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Semi-solid albumin solder improved mechanical properties for laser tissue welding
C B Bleustein1, C N Walker, D Felsen
1Department of Urology, New York-Presbyterian Hospital-Weill Medical College of Cornell University, New York, New York 10021, USA.
Background And Objective:
A semi-solid albumin solder formulated with hydroxypropylmethylcellulose (HPMC) was designed to improve the characteristics of liquid and solid solders.
Study Design/Materials And Methods:
Acute tensile strengths were determined on canine small bowel in vitro by using liquid 50% bovine serum albumin (BSA), semi-solid 48% BSA with HPMC, and solid 60% BSA solder. Long-term healing of liquid and semi-solid solders, compared with a suture control, was evaluated in a porcine skin model, with tensile strength as well as histologic findings obtained on postoperative day 7.
Results:
Acutely, semi-solid solder demonstrated a significantly (P < 0.05) higher tensile strength when compared with liquid or solid solder. At 7 days, HSA semi-solid and BSA semi-solid had significantly (P < 0.05) higher tensile strength than suture control; however, no differences were seen for liquid or solid solder groups. No differences in histology were appreciable between any of the solder groups in a porcine skin model.
Conclusion:
Acutely and at 7 days, semi-solid solder was stronger than 50% liquid albumin with better handling characteristics.