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N4-amino-acid derivatives of 6-azacytidine: structure-activity relationship
I Alexeeva1, L Palchikovskaya, A Shalamay
1Institute of Molecular Biology and Genetics NAS of Ukraine, Kiev. shved@imbig.kiev.ua
Acta Biochimica Polonica
|August 29, 2000
Abstract:
Several N4-derivatives of 6-azacytidine were synthesized using of Vorbrüggen's condensation method. Their antiviral activity with respect to the adenovirus serotypes 2 and 5 in Hep-2 cells culture was studied and primary specific activity was determined. Correlation between chemical structure of new 6-azacytidine derivatives and their biological properties is discussed.