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Related Experiment Videos

[Symptomatic pseudolithiasis caused by Rocephalin].

R Tuckuviene1, G S Myrtue

  • 1Sønderborg Sygehus, paediatrisk afdeling.

Ugeskrift for Laeger
|August 30, 2000
PubMed
Summary
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Ceftriaxone treatment can cause gallbladder pseudolithiasis, a condition where calcium salts precipitate. This case highlights a five-year-old girl who recovered after antibiotic change and symptomatic care.

Area of Science:

  • Pediatric Medicine
  • Pharmacology
  • Gastroenterology

Background:

  • Ceftriaxone, a third-generation cephalosporin antibiotic, is widely used for bacterial infections.
  • A known adverse effect of ceftriaxone is the formation of ceftriaxone-calcium precipitates in the gallbladder, termed pseudolithiasis.
  • This phenomenon is typically asymptomatic but can rarely cause symptoms.

Observation:

  • A previously healthy five-year-old girl was treated with ceftriaxone (brand name Rocephalin).
  • She developed symptomatic pseudolithiasis, presenting with gallbladder sludge and pain.
  • The patient's symptoms were managed with supportive care and a switch to a different antibiotic.

Findings:

  • The symptomatic pseudolithiasis resolved completely within days of discontinuing ceftriaxone and initiating alternative antibiotic therapy.

Related Experiment Videos

  • This case demonstrates a direct correlation between ceftriaxone administration and the development of symptomatic gallbladder pseudolithiasis in a pediatric patient.
  • The resolution of symptoms and pseudolithiasis upon antibiotic change confirms the causative role of ceftriaxone.

    • Implications:

    • Clinicians should be aware of the potential for ceftriaxone-induced gallbladder pseudolithiasis, even in pediatric populations.
    • Prompt recognition and management, including antibiotic modification, can effectively resolve this iatrogenic condition.
    • Further research may elucidate risk factors and optimal management strategies for ceftriaxone-associated pseudolithiasis.