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[Spectroscopic imaging (1H-2D-CSI) of the prostate: sequence optimization and correlation with histopathological
M Stanka1, E Eltze, A Semjonow
1Institut für Klinische Radiologie, Westfälische Wilhelms-Universität Münster. stanka@uni-muenster.de
Purpose:
Methodological optimization of a 1H MR spectroscopic imaging sequence (1H-2D-CSI) and evaluation of its potential to diagnose prostate cancer as validated by histopathological maps.
Methods:
The prostates of 18 patients were evaluated by 1H-MR-CSI (voxel dimension: 1 cm3) at 1.5 Tesla. This sequence was additionally combined with a frequency selective fat suppression.
Results:
It was possible to distinguish prostate carcinoma from prostate hyperplasia spectroscopically by the ratio of citrate/(choline + creatine). Differentiation of high-grade prostatic intraepithelial neoplasia (PIN, high-grade) from prostate carcinoma was not unambiguously possible. Prediction of tumor differentiation was not possible by the ratio of citrate/(choline + creatine) by our maximum spatial resolution of 1 cm3.
Conclusion:
1H-2D-CSI is suitable for tumor detection. Tumor differentiation was not possible with the spatial resolution used.