Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Introduction of a single isomer beta agonist.

J L Rau1

  • 1Cardiopulmonary Care Sciences, Georgia State University, Atlanta 30303, USA. jrau@gsu.edu

Respiratory Care
|August 30, 2000
PubMed
Summary

Levalbuterol, the first single-isomer beta agonist, is now available. Studies suggest its isomer, S-albuterol, may counteract bronchodilation, necessitating further research into single-isomer effects for asthma and COPD management.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

New horizons in respiratory care: the pharmacology of inhaled aerosol drug therapy.

Respiratory care·2000
Same author

Inhaled adrenergic bronchodilators: historical development and clinical application.

Respiratory care·2000
Same author

Combining a positive expiratory pressure device with a metered-dose inhaler reservoir system using chlorofluorocarbon albuterol and hydrofluoroalkane albuterol: effect on dose and particle size distributions.

Respiratory care·2000
Same author

The evolution of beta-agonists.

Respiratory care clinics of North America·1999
Same author

Recent developments in respiratory care pharmacology.

Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses·1999
Same author

Reservoir design and dose availability with long-term metered dose inhaler corticosteroid use.

Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine·1999

Area of Science:

  • Pharmacology
  • Respiratory Medicine

Background:

  • Levalbuterol is the first approved single-isomer beta-agonist for inhalation.
  • In vitro studies indicate S-albuterol may antagonize bronchodilation.

Purpose of the Study:

  • To evaluate the clinical impact of single-isomer levalbuterol compared to racemic albuterol.
  • To investigate the role of S-albuterol in bronchodilation.

Main Methods:

  • In vitro studies analyzing S-albuterol activity.
  • Clinical studies comparing levalbuterol with racemic albuterol (details not provided in abstract).

Main Results:

  • In vitro data suggest S-albuterol is not inactive and may oppose bronchodilation.
  • Clinical studies show some variability, indicating a need for further investigation.

Conclusions:

  • Levalbuterol's introduction provides a unique opportunity to study single-isomer beta-agonists.
  • Further clinical data will clarify the comparative effects of levalbuterol in asthma and COPD.

Related Experiment Videos