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CD1-restricted T-cell responses and microbial infection

S H Park1, A Bendelac

  • 1Department of Molecular Biology, Princeton University, New Jersey 08544, USA.

Nature
|August 30, 2000
PubMed

CD1, a conserved family of major histocompatibility (MHC)-like glycoproteins in mammals, specializes in capturing lipid rather than peptide antigen for presentation to T lymphocytes. The principles and mechanisms of this newly discovered immune strategy differ markedly from those governing classical MHC-peptide presentation. They might be exploited for the design of new lipid-based microbial vaccines and adjuvants.

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