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Preparation and characterization of cholic acid-derived antimicrobial agents with controlled stabilities
1Departments of Chemistry and Biochemistry and Microbiology, Brigham Young University, Provo, Utah 84602, USA.
Organic Letters
|August 31, 2000
Abstract:
[reaction: see text] Novel cholic acid-derived antimicrobial agents that decompose under mildly basic conditions have been prepared. These compounds range in biological properties from potent antibacterial activity to effective permeabilization of the outer membranes of Gram-negative bacteria.