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Efficient one-step conversion of primary aliphatic amines into primary alcohols: application to a model study for the
S M Rahman1, H Ohno, N Maezaki
1Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.
Organic Letters
|August 31, 2000
Abstract:
[reaction: see text] Treatment of primary aliphatic amines with KOH in diethylene glycol at 210 degrees C gives primary alcohols directly in good yields. A synthetic application to a model study of (+/-)-scopadulin is also described.