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Related Experiment Videos

Intercellular junctions: downstream and upstream of Ras?

J A Mercer1

  • 1McLaughlin Research Institute, 1520 23rd St South, Great Falls, MT 59405-4900, USA. umbjm@montana.edu

Seminars in Cell & Developmental Biology
|September 1, 2000
PubMed
Summary
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Ras signaling is crucial for understanding epithelial-mesenchymal transition in human tumors. This review explores how Ras impacts cell junctions and how these junctions influence Ras activity.

Area of Science:

  • Oncology
  • Cell Biology
  • Molecular Biology

Background:

  • Most human tumors originate from epithelial cells.
  • Epithelial-mesenchymal transition (EMT) is a process where epithelial cells lose their characteristics.
  • Activating RAS gene mutations are found in approximately 40% of human tumors.

Purpose of the Study:

  • To investigate the role of Ras signaling in epithelial-mesenchymal transition.
  • To understand the mechanisms and effectors through which Ras regulates intercellular junction formation in epithelial cells.
  • To explore the reciprocal regulation of Ras signaling by intercellular junction proteins.

Main Methods:

  • Literature review of studies on Ras signaling, EMT, and cell junctions.
  • Analysis of molecular mechanisms linking Ras pathways to cell adhesion molecules.

Related Experiment Videos

  • Examination of experimental evidence for crosstalk between junctional proteins and Ras effectors.

    • Main Results:

    • Ras signaling pathways are implicated in modulating the stability and dynamics of intercellular junctions during EMT.
    • Specific Ras effectors may directly influence the assembly or disassembly of adherens and tight junctions.
    • Intercellular junction proteins can act as regulators of Ras pathway activation, creating feedback loops.

    Conclusions:

    • Ras signaling plays a significant role in driving EMT by affecting epithelial cell adhesion.
    • Intercellular junction proteins are not only targets but also regulators of Ras signaling in the context of cancer.
    • Targeting the interplay between Ras and cell junctions may offer novel therapeutic strategies for epithelial cancers.