Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Relatedness testing in subdivided populations.

K L Ayres1

  • 1Department of Applied Statistics, University of Reading, P.O. Box 240, Earley Gate, RG6 6FN, Reading, UK. k.l.ayres@reading.ac.uk

Forensic Science International
|September 1, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluation of the time resolved fluorescence immunoassay (TRFIA) for the detection of varicella zoster virus (VZV) antibodies following vaccination of healthcare workers.

Journal of virological methods·2011
Same author

Persistence of varicella-zoster virus viraemia in patients with herpes zoster.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology·2010
Same author

Population genetic models can be used to study the evolution of the interacting behaviours of parents and their progeny.

Theoretical population biology·2007
Same author

DNA variation in a 13-Mb region including the F9 gene: inferring the genealogical history and causal role of a hemophilia B mutation (IVS 5+13 A-->G).

Journal of thrombosis and haemostasis : JTH·2003
Same author

Analysis of disputed single-parent/child and sibling relationships using 16 STR loci.

International journal of legal medicine·2002
Same author

Short tandem repeat profiling provides an international reference standard for human cell lines.

Proceedings of the National Academy of Sciences of the United States of America·2001
Same journal

Technical note: Development of a UHPLC-MS/MS method for the analysis of hCG and IGF-I from dried blood spots: A preliminary study.

Forensic science international·2026
Same journal

A novel and robust deep learning model for sibling firearm matching.

Forensic science international·2026
Same journal

Changes in C-reactive protein levels over time in high-temperature environments using postmortem blood.

Forensic science international·2026
Same journal

Insights from the first synthetic cannabinoid clandestine lab dismantled in Brazil.

Forensic science international·2026
Same journal

Determination of the new psychoactive substances MDMB-4en-PINACA, ADB-BUTINACA and some of their metabolites in blood and urine using DLLE-LC-MS/MS: application to real forensic case samples.

Forensic science international·2026
Same journal

The revolver halo as a forensic marker: Raman spectroscopic evidence of primer-driven gunshot residue deposition.

Forensic science international·2026
See all related articles

Calculating relationship probabilities from DNA requires a likelihood ratio (LR). This study adjusts LR calculations for population substructure using the coancestry coefficient F(ST), improving accuracy for related individuals.

Area of Science:

  • Forensic Genetics
  • Population Genetics
  • Statistical Genetics

Background:

  • Likelihood ratio (LR) calculations are crucial for DNA-based relationship probability assignments.
  • Standard LR calculations often assume genetic independence, which is inaccurate for individuals with recent shared ancestry due to population substructure.

Purpose of the Study:

  • To present adjusted likelihood ratio (LR) formulae that account for population substructure.
  • To incorporate the coancestry coefficient F(ST) into LR calculations for improved accuracy.
  • To address the impact of mutations in parentage testing.

Main Methods:

  • Development of adjusted LR formulae for various two-person relationships.
  • Inclusion of the coancestry coefficient F(ST) to model population substructure effects.

Related Experiment Videos

  • Analysis of mutation models relevant to parentage testing.

    • Main Results:

    • Provided adjusted LR formulae that are more appropriate for related individuals.
    • Demonstrated the impact of population substructure on LR values.
    • Offered considerations for mutation effects in parentage analysis.

    Conclusions:

    • Adjusted LR calculations using F(ST) enhance the accuracy of DNA-based relationship probabilities in the presence of population substructure.
    • Accurate genetic relationship testing requires accounting for population genetics principles.
    • Mutation models are an important consideration in parentage testing.