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Modulation of K(+)-induced synaptosomal calcium influx by gabapentin
1Pfizer Global Research & Development, Department of Neuroscience Therapeutics, Ann Arbor, MI 48105, USA. wolfgang.meder@wl.com
Brain Research
|September 1, 2000
Abstract:
Gabapentin, a drug useful in several neurological and psychiatric disorders, decreased K(+) (15 mM)-induced [Ca(2+)](i) increase in Fura-PE3-loaded rat neocortical synaptosomes (IC(50)=9.7 microM; submaximal inhibition of 28.6%). This effect may indicate a selective modulation of presynaptic Ca(2+) influx in response to depolarizing (pathological) conditions causing excessive neurotransmitter release.