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Related Experiment Videos

Interactions between vitamins C and E in human subjects.

I M Hamilton1, W S Gilmore, I F Benzie

  • 1Northern Ireland Centre for Diet and Health, University of Ulster, Coleraine, BT52 1SA, Northern Ireland, UK.

The British Journal of Nutrition
|September 1, 2000
PubMed
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This study provides in vivo evidence that vitamin C and vitamin E supplementation positively influence each other's plasma concentrations. Supplementation with either vitamin C or E also improved antioxidant status and lipid profiles in healthy adults.

Area of Science:

  • Biochemistry
  • Human Nutrition
  • Antioxidant Research

Background:

  • In vitro studies suggest a synergistic interaction between vitamins C and E.
  • In vivo confirmation of this interaction remains limited.
  • Understanding nutrient interactions is crucial for optimizing health benefits.

Purpose of the Study:

  • To investigate the in vivo interaction between vitamin C and vitamin E.
  • To assess the effects of vitamin C and E supplementation on plasma concentrations of these vitamins and other antioxidants.
  • To evaluate the impact on lipid profiles and hemostatic variables.

Main Methods:

  • Double-blinded, placebo-controlled crossover study with 30 healthy adults.
  • Supplementation with ascorbic acid (vitamin C) or RRR-alpha-tocopherol acetate (vitamin E) for 6 weeks.

Related Experiment Videos

  • Blood samples collected pre- and post-intervention to measure plasma vitamin levels, antioxidants, lipids, and hemostatic markers.

    • Main Results:

    • Ascorbic acid supplementation increased lipid-standardized alpha-tocopherol levels (P < 0.05).
    • (RRR)-alpha-tocopherol supplementation increased plasma ascorbic acid levels (P < 0.05).
    • Both vitamin C and E supplementation enhanced plasma antioxidant capacity and reduced lipid levels.

    Conclusions:

    • The findings support an in vivo interaction between vitamins C and E.
    • Supplementation with one vitamin positively affects the plasma levels of the other.
    • This interaction may contribute to improved antioxidant status and cardiovascular health.